Gaming

Minecraft blind playthrough by PiroPito (Japanese w/ eng sub)

LetsGameItOut - Josh (and Anthony if you go back in time a little) gaming it out. Could be classed as comedy but I'm thinking of the older content here, though I'm a fan of the new stuff too. Also fun to catch on twitch.

DougDoug - I'm at a loss to describe him. Probably not for everyone but I find it funny.

Humour

Half Life VR but the AI is Self Aware - Comedy Improv Series

Jehtt - Meme channel

Real Time Fandubs - Improvised Dubs

Sonic Destruction - Real Time Fandubs cast voice act an ai generated sonic film.

Music

Turbo - Eurobeat Remixes

Matthew Ifield - Beautiful voice, does covers and original songs!

Frank Watkinson - Lovely covers and originals by your new replacement grandfather <3

Misc

Snapcube AKA Penny Parker - She sings, she games, she makes you laugh.